摘要
为评价三羟甲基氨基甲烷（ＴＨＡＭ）治疗重型颅脑损伤合并脑乳酸中毒的作用，作者将５０例脑外伤合并脑乳酸中毒的患者随机分为ＴＨＡＭ组和对照组，各２５例。同期行颅内压监测，脑脊液ｐＨ值和乳酸值测定。结果表明，ＴＨＡＭ组明显好于对照组。ＴＨＡＭ可有效地提高脑脊液ｐＨ值，降低脑脊液（ＣＳＦ）乳酸和颅内压水平，并能改善预后。作者还对ＴＨＡＭ的药理基础和疗效进行讨论。
Thepresenceoflacticacidosisinthecerebralspinalfluidof50patientswithsevereheadinjurywasstudied.TheGCSscoresofthesepatientswere≤8.Thepatientsweredividedintotwogroups.Wetreated25patientswithadoseof4to5ml/kgofTHAMinfusedintravenously2to3timesfordailyadministration.Other25patientswhowerenottreatedwithTHAMservedasacontrolgroup.Ineachcase,aventricularpresuremonitoringdevicewasinstaled.TheICPwasthencontineouslyrecorded.Inaddition,laboratorystudy,includinglactate,pH,HCO-3andBEinCSFwasperformed.THAMinfusionwasassociatedwithimprovedsurvival,decreasedICPascomparedtothatinthecontrolgroup.WebelivethatTHAMtreatmentmaysignifcantlyimprovetheprognosisofpresenceoflacticaci-dosisasaresultofsevereheadinjury.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1996年第6期364-367,共4页
Chinese Journal of Surgery
