摘要
为评价三羟甲基氨基甲烷(THAM)治疗重型颅脑损伤合并脑乳酸中毒的作用,作者将50例脑外伤合并脑乳酸中毒的患者随机分为THAM组和对照组,各25例。同期行颅内压监测,脑脊液pH值和乳酸值测定。结果表明,THAM组明显好于对照组。THAM可有效地提高脑脊液pH值,降低脑脊液(CSF)乳酸和颅内压水平,并能改善预后。作者还对THAM的药理基础和疗效进行讨论。
Thepresenceoflacticacidosisinthecerebralspinalfluidof50patientswithsevereheadinjurywasstudied.TheGCSscoresofthesepatientswere≤8.Thepatientsweredividedintotwogroups.Wetreated25patientswithadoseof4to5ml/kgofTHAMinfusedintravenously2to3timesfordailyadministration.Other25patientswhowerenottreatedwithTHAMservedasacontrolgroup.Ineachcase,aventricularpresuremonitoringdevicewasinstaled.TheICPwasthencontineouslyrecorded.Inaddition,laboratorystudy,includinglactate,pH,HCO-3andBEinCSFwasperformed.THAMinfusionwasassociatedwithimprovedsurvival,decreasedICPascomparedtothatinthecontrolgroup.WebelivethatTHAMtreatmentmaysignifcantlyimprovetheprognosisofpresenceoflacticaci-dosisasaresultofsevereheadinjury.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1996年第6期364-367,共4页
Chinese Journal of Surgery