摘要
目的:探讨原因不明性反复自然流产患者在主动免疫和被动免疫治疗前后Th1/Th2型细胞因子和NK细胞的变化。方法:采用流式细胞仪对被动免疫25例和主动免疫38例原因不明性反复自然流产者进行治疗前后Th1/Th2型细胞因子和NK细胞含量的检测比较,同时以20例正常妊娠妇女作为对照。结果:在主动免疫和被动免疫治疗前与对照组相比,Th2型细胞因子IL-10显著下降,主动免疫和被动免疫治疗后,Th1型细胞因子IFN-γ和NK细胞含量明显下调。结论:原因不明性反复自然流产患者经主动免疫和被动免疫治疗后,Th1/Th2型细胞因子和NK细胞含量有明显改变。
Objective: To investigate the changes of Th1/Th2 type cytokines and NK cells in unexplained recurrent spontaneous abortion women before and after initiative immunotherapy and passive immunotherapy. Methods: Flow Cytometry was used to measure Th1/ Th2 type cytokines and NK cells of unexplained recurrent spontaneous abortion women before and after 38 initiative immunotherapy and 25 passive immunotherapy, and control as 20 normal pregnant women. Results: Th2 type cytokine IL - 10 levels were significantly elevated before the initiative and passive immunotherapy. Whereas Thl type cytokine IFN - γ and NK cells were significantly down - regulated after the initiative and passive immunotherapy. Conclusion: Th1/Th2 type cytokines and NK cells are significantly changed in unexplained recurrent spontaneous abortion women after initiative immunotherapy and passive immunotherapy.
出处
《中国妇幼保健》
CAS
北大核心
2005年第20期2637-2639,共3页
Maternal and Child Health Care of China
关键词
反复自然流产
TH1/TH2型细胞因子
NK细胞
流式细胞仪
主动免疫被动免疫
Unexplained recurrent spontaneous abortion
Th1/Th2 type cytokines
NK cells
Flow Cytometry
Initiative immunotberapy
Passive immunotherapy