人微小病毒B_(19)宫内感染对妊娠结局的影响

Effects of B_(19) Virus during pregnancy on the pregnant outcome

目的:探讨妊娠期妇女微小病毒(B19)感染对妊娠结局的影响。方法:采用酶联免疫吸附法(ELISA)检测2 990例孕妇外周血及新生儿脐血Tox-IgM,孕妇148例阳性者为感染组,160例阴性者为非感染组,分析两组胎婴儿的生长发育情况;并对4例先天感染的婴幼儿进行追踪观察。结果:感染组孕妇发生流产(31.08%)、FGR(4.05%)、胎儿畸形(3.38%)、其他异常妊娠(8.78%)、死胎2例(1.35%);非感染组发生流产(8.75%)、FGR(2.50%)、胎儿畸形(1.25%)、其他异常妊娠(3.75%),没有死胎病例。两组比较,差异有极显著性(P<0.01)。新生儿感染率13.79%,且出现神经系统损害及贫血的临床表现。结论:妊娠期妇女感染B19病毒与妊娠不良结局密切相关。重视孕期感染性疾病的防治,对优生优育具有重要的意义。

Objective： To explore prospectively the effect of B19 Virus during pregnancy on the pregnant outcome. Methods： 2 990 pregnant women＇s blood and 2 990 newborns＇s umbilical blood were detected by ELISA. 148 pregnant women with Tox - IgM positive were re- garded as infection group （ study group）, 160 pregnant women with Tox -IgM negative were regarded as control group. To analyze the physical and mental development of infants of two groups, and 4 infants with intrauterine transmission were followed up. Results： The abortion rate of infection group was 31.08%, rate of FGR was 4. 05% , rate of monstrosity was 3.38%, rate of other abnormal pregnancies was 8. 78%, and rate of dead - birth was 1.35% （2 cases） . The rates in control group were 8. 75%, 2. 50%, 1.25%, 3.75% respectively and no dead -birth. Statistical analysis revealed significant difference between two groups. Conclusion： There is an intimate association between Bt9 Virus during pregnancy and bad pregnancy outcomes. There is an important significance for prepotency to pay attention to the prevention and therapy of infective diseases during pregnancy.