复方甘草酸苷联合熊去氧胆酸治疗慢性乙型肝炎的疗效观察

Therapeutic Effect Observation on Chronic Hepatitis B Treated with Compound Glycyrrhizin Plus Urˉsodeoxycholic Acid

目的:观察复方甘草酸苷联合熊去氧胆酸治疗慢性乙型肝炎的疗效。方法:87例慢性乙型肝炎患者均为抗病毒治疗失败或肝功能长期异常者,随机分为治疗组(47例)和对照组(40例),分别给予复方甘草酸苷+熊去氧胆酸和复方甘草酸苷+维生素C治疗,疗程均为8wk。结果:治疗组在肝功能、免疫功能改善方面优于对照组(P<0.05);治疗组与对照组总有效率分别为89.4%、67.5%(P<0.01)。结论:复方甘草酸苷联合熊去氧胆酸治疗抗病毒失败或肝功能长期异常者有效。

OBJECTIVE： To observe the therapeutic effect of the treatment of chronic hepatitis B. METHODS： 87 patients with compound glycyrrhizin combining ursodeoxycholic acid in chronic hepatitis B were enrolled to, on whom, the anti - viral therapy proved to be ineffective and who suffered a long - term abnormal liver functions, of the total, 47 were randomly assigned to receive compound glycyrrhizin plus ursodeoxycholic acid（treatment group）, and 40 to receive compound glycyrrhizin plus vitamin C（control group）. Course of treatment for both groups was 8 weeks. RESULTS： As compared with the control group, the liver function arid immune function for the treatment group had a better amelioration（P〈 0.05）; the total effective rates of the treatment group and the control group were 89.4% and 67.5% （P 〈0.01）, respectively. CONCLUSION： Compound glycyrrhizin plus ursodeoxycholic acid is effective in therapy is ineffective and whose liver functions are abnormal for the treatment of chronic hepatitis B cases when anti - viral a long time.