脑梗死患者血清C-反应蛋白水平变化及临床意义

Serum C-reactive protein level changes and clinical significance in patients with cerebral infarction

目的观察脑梗死患者不同时期血清C-反应蛋白(CRP)的变化及病情的严重性和预后的关系,探讨脑梗死患者不同时期血清CRP水平的临床意义。方法对病程在2周以内的90例脑梗死患者在入院时及1周后进行血清CRP水平的测定,应用美国国立卫生研究院卒中量表及Barthel指数记分对入选患者在入院时及3个月后的神经功能缺损程度进行评分。结果入院时的CRP水平低于入院1周后的CRP水平,但其差异无显著意义。前者与患病当时及病后3个月神经功能缺损的严重程度显著相关,且这种相关性存在着量化的关系,而后者则无此相关。结论根据脑梗死患者病后2周内的CRP水平可以对病情的严重性及预后进行量化的判定。

Objectives To investigate the changes of serum C-reactive protein （CRP） concentration in patients with cerebral infarction and to determine whether the levels of CRP correlate with severity and outcome after ischemic stroke, Methods Ninety patients with ischemic stroke no more than 2 weeks after symptom onset were examined with National Institutes of Health Stroke Scale （NIHSS） and Barthel Index （BI） score on admission and 3 months after admission. CRP measurement was done on admission and 1 week after admission. Results The level of CRP measured within 2 weeks after symptom onset was lower than that measured 1 week later, the difference was not significant. The former correlated significantly with severity and outcome after ischemic stroke, the correlation was quantitative, In contrast, the latter did not correlate with severity and outcome after cerebral infarction. Conclusions The levels of CRP measured within 2 weeks after symptom onset are correlated with severity and can predict the outcome after ischemic stroke. The correlations are quantitative.