体内外血液净化治疗重型肝炎临床研究

Clinical Study on Blood Purification in Severe Hepatitis in Vivo and Vitro

目的:探讨血液净化联合中医通里攻下、抗内毒素血症(即体内外血液净化)治疗重型肝炎的临床价值。方法:应用血液净化治疗重型肝炎前(Ⅱ组)或同时(Ⅲ组),加用有效中药制剂并与单纯用血液净化(Ⅰ组)比较。结果:Ⅱ组患者血液中的内毒素、过氧化脂质、肿瘤坏死因子、胆红素水平明显下降,明显低于Ⅰ、Ⅲ组,差异有统计学意义(P<0.05或P<0.01)。Ⅱ组最终病死率为45.45%,Ⅰ、Ⅲ组患者的病死率均为71.4%,但差别无统计学意义。结论:体内外血液净化方法可减少有害物质的继续产生和吸收,提高疗效。

Objective： To study the effect of blood purification combined with traditional Chinese medicine in severe hepatitis in vivo and vitro. Methods： All severe hepatitis patients were randomly divided into three groups including simple blood purification in group Ⅰ, traditional Chinese medicine added before and at the same time with blood purification simultaneity in group Ⅱ and group Ⅲ. Results： The levels of endotoxin （ET）, lipid peroxide （LPO）, tumor necrotic factor （TNF） and bilirnbin （BIL） obviously decreased in group Ⅱ which significantly lower than those of group Ⅰ and group Ⅲ （P 〈 0.05 and P 〈 0.01）. Final mortality rates were 45.45 % in group Ⅱ and 71.4% in group Ⅰ and group Ⅲ. There were no significant differences between three groups. Conclusion： Blood purification can reduce the continuous generation and absorption of toxic substances and improve the curative effect.