CO_2激光照射活体皮肤的光热效应研究

Research on Photo-thermal Effect of in Vivo Skin Irradiated by CO_2 Laser

结合温度测量和数值模拟进行激光与组织光热效应的研究。采用二维有限元法求解生物热传输方程,可计算得到组织的模拟温度分布。温度测量可用来验证理论模型,采用微型热电偶与红外辐射测温仪同时测量生物组织内部和表面照射点温度,适于组织微创和快速的点温测量。CO2激光凝结活体大鼠皮肤组织的实验和数值分析结果显示温度响应曲线形状基本一致,表面照射点(r=0 mm,z=0mm)和皮下(r=0 mm,z=1 mm)温度的峰值相对误差分别为23.24%和0.4%,灌注率和位置是温度曲线的主要影响因素,所以准确的组织参数和更精确的定位可以进一步降低误差,为激光治疗提供直观、全面和可预知的信息。

This paper has combined temperature measuring and numerical simulation to research the laser and tissue photo-thermal effect. Two dimensions finite elment method was used to solve the bio-heat transfer equation and the tissue simulation temperatures were computed. Temperature measuring can be used to verify the therory model. Miniature thermocouple and infrared radiation thermometer were used to monitor the inner and surface bio-tissue temperature synchronously,which is suitable to minimally invasive and rapid mi- nute point tissue temperature measuring. The experiment results of 002 laser coagulated in vivo mouse skin experiments and numerical simulation results showed the temperature response curve shape were almost accordant, the surface irradiation point （ r =0 mm, z = 0 mm） and the subcutaneous （r=0 mm, z=1 mm） temperature peak value relative error was around 23.24% and 0.4% respectively. Perfusion rate and position were the main influence factor of temperature curve,therefore exact tissue parameters and more precise orientation can further decrease the error and provide straight,complete and predictive information for the laser therapy.