农村男性接触有机磷农药对精液质量影响的研究

Influence of Organophosphorus Pesticide on Semen Quality of Men in Rural Areas of Changshu City

目的:研究慢性低剂量接触有机磷农药对男性生殖机能影响。方法:筛选161名男性为有机磷农药暴露组,161名为非暴露组,进行流行病学问卷调查、外生殖器检查和精液样本的采集和测定。结果:发现长期接触小剂量有机磷使精子密度明显下降,精子密度暴露组为76·0±84·8×106/ml,非暴露组为100·0±56·4×106/ml(P=0·0059);农药与精子质量Logistic回归分析发现,暴露组精子质量明显下降,两组相比较其差异有显著统计学意义;暴露组的性欲降低,性交次数减少。结论:本研究发现农民因防护不当、长期小剂量接触有机磷农药可导致生殖机能下降,因此要加强农村农药中毒的防治工作,杜绝慢性中毒事件发生,保护农民身体健康,促进农业生产发展。

Objective： To study the influence of low - dose chronic organophosphorus pesticide on male reproductive function. Methods： 161 men in exposed group and 161 ones in unexposed group received epidemiological questionnaires investigation, genital examinations and semen sample collection and measurement. Results：The semen density of the men who usually touched low -dose organophosphorus pesticide was declining obviously, and the semen density in exposed group and in unexposed group were76.0 ± 84.8 × 10^6/ml and 100.0 ± 56.4 × 10^6/ml （ P =0.0059）, respectively. The logistic regressionanalysis showed that semen quality and sexual desire of exposed group significantly reduced. Conclusion： The low-dose chronic pesticide contact without enough protection measurements can lead to decline of reproductive function. So we should strengthen the prevention and improve reproductive health.