一阶导数分光光度法测定IMC－TMP栓的含量

First order derivative UV spectrophotometry of indomethacin and trimethoprim in suppository

采用一阶导数分光光度法可消除栓剂中两种药物相互干扰而分别测定其含量，方法快速简便。吲哚美辛检测波长为３４１ｎｍ，平均回收率为９８．９０±１．９３％（ｎ＝５）；甲氧苄氨嘧啶检测波长为２６３ｎｍ，平均回收率为９８．７３±０．７４％（ｎ＝５）。

ndomethacin(IMC)and trimethoprim (TMP)in suppository were quantitatively determined by first order derivative UV spectrometry.The determining wavelengthes were 341nm and 263nm,and the average recoveries were 98.90±1.93% and 98.73±0 74%,respectively. The method is convenient and fast.