血清sIL－2R检测在儿童血液病中的变化及意义

Change and Its Significance of Serum Soluble Interleukin-2 Receptor (sIL-2R) Level in Children with Hematological Diseases

应用双抗体夹心酶联免疫吸附法测定３９例血液病患儿血清可溶性白介素２受体（ｓＩＬ－２Ｒ）水平，结果发现：急性淋巴细胞性白血病（ＡＬＬ）组血清ｓＩＬ－２Ｒ水平为（２１８．８８±７６．９８）ｋＵ／Ｌ，急性非淋巴细胞性白血病（ＡＮＬＬ）组为（４１１．６７±２２８．４５）ｋＵ／Ｌ骨髓增生异常综合征（ＭＤＳ）组为（３３９．５０±９２．０３）ｋＵ／Ｌ非何杰金淋巴瘤（ＮＨＤ）组为（４２５．５０±１３７．０５）ｋＵ／Ｌ，各组均明显高于对照组（９３．３±２２．７）ｋＵ／Ｌ，且随病情的变化而变化。ＡＬＬ、ＡＮＬＬ组患儿血清ｓＩＬ－２Ｒ水平，完全缓解期与正常组比较，无显著差异；ＮＨＤ组患儿血清ｓＩＬ－２Ｒ水平越高，病情越重。我们认为血液病患儿血清ｓＩＬ－２Ｒ增高与机体免疫异常及病情严重程度相关，故检测血清ｓＩＬ－２Ｒ水平，可为临床观察病情、监测疗效、估计预后提供重要参数。

Using ELISA method was detected serum sIL-2R level in children with hematological diseases. The results indicate that children with hematological tumors(ALL 、ANLL、MDS、NHD)have high sIL-2R levels.The level of serum sIL-2R in children with leukemia in complete remission is far lower than in cases in partial remission and its level in children with NHD decreases with good response to chemotherapy;whereas in children with MDS is related to subtypes of MDS.Cases with aplastic aneamia and idiopathic thrombocytopenic purpura have normal sIL-2R levels.Therefore,serum sIL-2R in children with hematological tumor can serve as a useful maker in the evaluation of drug-action as well as in diagnosis and prognosis.