二联活菌洁阴制剂治疗念珠菌性阴道炎动物模型的实验研究

Double-valent Live Germ Agent for Therapy of Experimental Candidal Vaginitis

目的观察二联活菌洁阴制剂体内治疗动物模型念珠菌性阴道炎的疗效。方法将致病菌直接注入新西兰大白兔阴道内制成相应的阴道炎模型,将高、中、低3个剂量的二联活菌菌粉作为治疗组,同时设氟康唑组和生理盐水对照组,治疗观察7 d。结果中、高剂量的二联活菌菌粉的疗效与氟康唑组相近,治愈率均可达83%。结论二联活菌制剂具有与氟康唑接近的疗效,同时也是重建阴道内微生态正常菌群的一种新型的治疗手段。

OBJECTIVE To observe the effect of therapy for the candidal vaginitis in animal by double-valent live germ agent. METHODS The pathogens were directly injected into the vagina of New Zealand white rabbits in order to make candidal vaginitis model, then,all the rabbits were treated with the drugs intravaginally and had been observed for seven days, they were divided into two groups, the therapy group was using high or low dosage of double-valent live germ agent, the controll group was by ketoconazole. RESULTS The effect of using high dosage of double-valent live germ agent was the same as of the ketoconazole, and the recovery rate both was 83%. CONCLUSIONS The double live germ agent not only has the same effect as the ketoconazole in treating the candidal vaginitis, but also can rebuild the vaginal normal germs to protect the tiny environment.