耐亚胺培南铜绿假单胞菌的分布及耐药性分析

Antibiotic-resistant Spectra of Imipenem-resistant Pseudomonas aeruginosa

目的了解耐亚胺培南铜绿假单胞菌的分布及对抗菌药物的敏感性。方法利用K-B法、琼脂扩散法、微量稀释法测定临床铜绿假单胞菌与耐亚胺培南铜绿假单胞菌对抗菌药物的敏感性。结果耐亚胺培南铜绿假单胞菌尤其是多重耐药铜绿假单胞菌在ICU和老年病房比普通病房更加严重,对照组对抗菌药物的耐药率明显低于耐亚胺培南铜绿假单胞菌。结论铜绿假单胞菌对阿米卡星、环丙沙星、头孢哌酮/舒巴坦的效果都不错,耐亚胺培南铜绿假单胞菌选择抗菌药物的范围很窄,只有阿米卡星的活性较好。

OBJECTIVE To investigate the distribution of imipenem-resistant Pseudomonas aeruginosa （R-Imp PAE） and their reactions to other antibiotics. METHODS K-B disc-diffusion, agar-diffusion and micro-dilution methods were applied to test the sensitivity to antibiotics of clinical isolated PAE and R-Imp PAE strains. RESULTS PAE,especially from ICU wards and aged wards were more resistant than those from ordinary wards. The resistant rates of PAE strains from control group were much lower than that of R-Imp PAE. CONCLUSIONS Amikacin, ciprofloxacin and cefoperazone/sulbactam are effective to PAE. But selection of antibiotics is limited for R-Imp PAE, with the best presentation of amikacin only.