家兔挤压综合征血液高凝与肾脏微循环障碍的关系

The Relationship Between Hypercoagulation and Glomerular Microcirculation Disorder in Crush Syndrome in Rabbits

报道14只家兔挤压综合征(CS)时,血液高凝与肾脏微循环障碍的关系。采用本组研制成功的CS动物模型。伤后1～5天纤维蛋白元、血小板和伤后2、5天血浆渗透压均显著升高,伤后24小时内试管内凝血时间显著缩短,伤后三P试验阳性率逐日增加,肾小球毛细血管内皮细胞等肿胀、肥大、增生、脱落致毛细血管腔狭窄、闭塞。CS早期血液呈非常显著的高凝状态,甚至毛细血管内血凝,肾微循环严重障碍。这些改变是CS尿少的主要原因。

Experimental crush syndrome was produced in 14 rabbits, The relationship between hypercoagutation and glomerular miciocirculation was studied, It was found that fibrinogen, platelet count increased and plasma osmotic pressure rose from the first to the fifth day and from second to the fifth day after injury, respectively. Coagulation time （ test tube method ） was shortened significantly on the first day after the infliction of injury. The 3P tests became positive more and more obviously with the time after injury. The endothelial cells in glomerula capillaries showed swelling, hypertrophy, proliferation and desquamation which led to narrowing or even blocking of the lumens of the glomerular capillaries. Hypercoagulation together with pathological changes in glomerular capillaries were considered as the chief mechanism of the reduction in urine excretion in crush syndrome.