3H－1，2－二氢－1－吡咯里嗪酮衍生物的合成

Synthesis of 3H-1,2-Dihydro-1-Pyrrolizinone Derivatives

实验证实３Ｈ－１，２二氢－１－吡咯里嗪酮（Ａ）及５－（４－氯苯甲酰基）３Ｈ－１，２－二氢－１－吡咯里嗪酮（Ｂ）具有明显的抗炎镇痛作用。在此基础上，设计合成了Ａ的１２个Ｍａｎｎｉｃｈ碱衍生物Ｃ（１－１２）及Ｂ的缩氨脲Ｄ１和肟Ｄ２，这１４个化合物均未见文献报道。药理实验证明，这些化合物大多具有抗炎镇痛活性，其中化合物Ｃ１、Ｃ２、Ｃ３、Ｃ９活性最为显著。

H-1, 2-Dihydro-1-pyrrolizinone and 5-(4-Chlorobenzoyl) 3H-1,2 -dihydro-1-pyrrolizinone were found to have significant anti-inflammatory and analgesic action, Fourteen 1-pyrrolizinone derivatives were synthesized which had not been reported in the literature ever before. Pharmacological tests showed that most of them had remarkable anti-inflammatory and analgesic activities.