去极化作为电压门控性钙通道的调节信号

Depolarization as a regulatory signal at voltage gated calcium channels

去极化作为电压门控性钙通道的调节信号ＤａｖｉｄＪＴＲＩＧＧＬＥ（Ｄｅａｎ，ＴｈｅＧｒａｄｕａｔｅＳｃｈｏｏｌ，ＳｔａｔｅＵｎｉｖｅｒｓｉｔｙｏｆＮｅｗＹｏｒｋ，ＢｕｆｆａｌｏＮＹ１４２６０，ＵＳＡ）关键词钙通道；膜电位；神经生理学；电生理学；钙通道激...

Changes in membrane potential are a regulatory signal for voltage gated ion channels including the family of Ca 2+ channels. This regulatory role includes the voltage dependent opening, closing, and inactivation of ion chnnels and the control of drug access and affinity for discrete channels states. Membrane potential is both a short and long term regulatory signal controlling the number and function of these voltage gated channels. Depolarization of neuronal and neurosecretory cells produces down regulation of L type voltage gated Ca 2+ channels. These processes are described and their relevance to physiologic and pathologic processes of neuronal development and neuroprotection are indicated.