急性白血病病人化疗后的血液学及生化变化

Hematological and biochemical changes in acute leukemic patients after chemotherapy 1

急性白血病病人化疗后的血液学及生化变化ＡｚｍａｔＲＡＳＨＥＥＤ，ＡｓｉｆＩＱＴＩＤＡＲ，ＳｈａｈｂａｚＫＨＡＮ（ＰｈａｒｍａｃｏｌｏｇｙＳｅｃｔｉｏｎ，ＦａｃｕｌｔｙｏｆＰｈａｒｍａｃｙ，ＵｎｉｖｅｒｓｉｔｙｏｆＰｕｎｊａｂ，ＯｌｄＣａｍｐｕｓ，Ｌａ...

AIM: To study hematological and biochemical profiles in acute leukemic patients before and after chemotherapy. METHODS: Sera from 20 normal persons were compared with those from 40 patients of whom 20 patients were followed up after 6-8 months of treatment with cyclophos￣phamide, vincristine, and prednisolone. RESULTS: Hemoglobin, hematocrit and platelet count were decreased while reticulocyte count, blood sedimmentation, total leukocyte count, bleeding time, bilirubin, blood coagulation time, alanine aminotransferase, lactate dehydro￣ genase, creatin￣ine, and urea were increased in acute myelocytic patients compared to normal. A similar pattern was observed in acute lymphocytic patients except there was no significant increase in serum urea. CONCLUSION: In acute leukemic patients blood chemistry and hematology are useful during diagnosis and treatment. After 6-8 months of treatment 50 % remission occurred.