复方灭滴灵局部应用对创伤厌氧菌感染的防治作用

Prophylactic and Therapeutic Effect of Local Application of Compound Metronidazole against Anaerobic Infection of the Wound

用切割和挤压法使豚鼠后腿肌肉损伤,伤口用灭菌泥土和产气荚膜梭菌污染。未治疗的对照组动物有75%死于严重的产气荚膜梭菌感染,伤口内检出的细菌以产气荚膜梭菌为主。在伤口被污染后4小时用复方灭滴灵做局部治疗,治疗组动物活存率为94.4%(p<0.01);伤口内未检出产气荚膜梭菌。结果表明,局部应用复方灭滴灵防治创伤厌氧菌感染是有效的。

Experemental injury of muscles of hind leg of gulnea-pigs were created with incision and crushing. The wounds were then contaminated with sterile soil and clostridium perfringens in experiments. In the treated animals which were given local compound metronidazole at 4 hours after injury, the survivol rate of animals was 95.4%（p〈0.01）. Seventy-floe percent of untreated animals died from severes CI perfringens infection In untreated group, the organism detected in the wounds were CI, perfringens predomlnantly, but CI. perfringens were absent in those treated with compound metronidazole group.The results indicate that local application of compound metronidazole is effective for prevention and treatment of anaerobic infection after injury.