冲击伤时心肌细胞膜通透性改变的初步观察

Preliminary Observation on Cellular Membrane Permeability of Myocardium in Blast Injury

本实验利用硝酸镧电镜示踪技术观察了大鼠经受冲击波后不同时限心肌细胞超微结构及细胞膜通透性的变化.这些变化包括。①心肌细胞膜通透性增加较超微结构改变出现早,恢复慢;②心肌细胞膜通透性增加呈局限性分布;③心肌细胞膜通透性增加以伤后6、24小时组为显著;④进入心肌细胞的镧颗粒主要分布在线粒体周围及肌微丝上。发生这些变化的可能原因是:①冲击波的直接效应;②应激反应;③肺部病变的影响。

Lanthanum nitrate was used as a tracer for electron density to show changes of ultra-structure and cell membrane permeability of myocardium at various intervals after bIast exposure in rats The main Changes in myocardium were as follows： （1） In comparison with the changes of ultra-structure, the increase of cell membrane permeability appeared earlier, recovered more slowly and distributed broader in ranges （2） The increase of cell membrane permeability was local; （3） The increase of permeability was found higher at 6 and 24hr after blast exposure; （4） Lanthanum particles that entered myocardial cell were mainly distributed to the area around mitochondria and myofilaments. possible factors in relevance ares （1） the direct effects of blast wave; （2） the stress reaction; （3） the secondary effects on lung after blast injury.