口腔鳞癌C－erbB－1蛋白产物表达的临床意义

EXPRESSION AND CLINICAL SIGNIFICANCE OF C-erbB-1 ONCOGENOUS PROTEIN IN ORAL SQUAMOUS CELL CARCINOMA

用兔抗人表皮生长因子受体（ＥＧＦＲ）抗体和免疫组化ＡＢＣ法，检测了口腔鳞状细胞癌４３例，２５例出现ＥＧＦＲ超量表达，其表达水平与肿瘤分化程度无关。在伴有淋巴结转移的病例或晚期鳞癌中，ＥＧＦＲ超量表达的出现率明显多于无淋巴结转移的病例或早期鳞癌。提示ＥＧＦＲ超量表达与口腔癌生物学行为之间有一定的关系，可作为评估口腔癌转移风险及其预后的指标。

Forty-three cases of oral squamous cell carcinoma were examined immunohistochemically by the avidin-biotin peroxidase complex method with anti-epidermal growth factor receptor (EGFR) polyclonal antibody. 25 cases were shown to have EGFR overexpression,and no association was found between EGFR level and the degree of tumour differentiation.The rate of EGFR overexpression was significantly higher in cases with lymphnode metastases than in cases without lymphonode metastases, and in advanced tumour stages than in early tumour stages.The results suggested that EGFR overexpression might have some relationship to the biological behavior of the oral carcinoma and could be used as a useful marker for assessing the risk of lymphnode metastasis and the prognosis of oral carcinoma.