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乳酸-羟基乙酸共聚物(PLGA)微球控释系统的突释 被引量：9

The initial burst of PLGA microparticle systems
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摘要 目的介绍近年来国内外对乳酸-羟基乙酸共聚物(PLGA)微球控释系统的突释的研究。方法分析有关文献资料,对产生突释的原因、影响突释的因素以及减少突释的方法进行详细介绍。结果和结论突释通常是不受欢迎的,随着对突释原因的深入了解,突释问题应能得到解决和控制。 OBJECTIVE To review previous research conducted to control the initial burst in poly （ lactic-co-glycolic acid） （ PLGA） microparticle systems. METHOD The cause of initial burst, the formulation parameters affecting initial release and approaches to reduce initial burst were all analyzed according to relevant literatures. RESULTS and CONCLUSION The burst release is usually not effective and welcome, it should be well controlled by studying the initial release problem thoroughly.
作者 叶美娣 郑彩虹
机构地区 浙江省湖州市第一医院药剂科 浙江大学医学院附属妇产医院
出处 《中国现代应用药学》 CAS CSCD 北大核心 2005年第5期371-374,共4页 Chinese Journal of Modern Applied Pharmacy
关键词 乳酸-羟基乙酸共聚物 微球 突释 制备参数 PLGA microsphere initial burst formulation parameters
分类号 R943.4 [医药卫生—药剂学]
  • 相关文献

参考文献25

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  • 2Takenaga M, Yamaguchi Y, Kitagawa A, et al. A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release[J]. J Controlled Release, 2002, 79 ( 1-3 ) :81-91.
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  • 4Walter Elke, Dreher Donatus, Kok Menno, et al. Hydrophilic poly( dl-lactide-co-glycolide ) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells[J]. J Controlled Release, 2001 , 76(1-2) : 149-168.
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二级参考文献26

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共引文献28

同被引文献96

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二级引证文献30

中国现代应用药学
2005年 第5期

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