摘要
目的:观察白藜芦醇对实验性高脂血症大鼠脂代谢的影响。方法:喂饲法建立高血脂症大鼠模型,白藜芦醇按30、70mg/kgbw·d给大鼠连续灌胃4w,测定血清TC、TG、LDL-c、HDL-c、apoAI、apoB、AST、ALT含量,肝脏脂质含量及肝脏中LPL、HL活性,粪胆汁酸含量。结果:白藜芦醇能明显降低TC、TG、LDL-c、apoB、AST、ALT,促进粪胆汁酸排泄,使AI降低,HDL-c/TC及apoAI/apoB比值升高,并能提高高脂血症大鼠肝脏LPL、HL活性。结论:白藜芦醇能调节高脂血症大鼠脂代谢,发挥抗动脉硬化作用。
Objective： To observe the effect of resveratrol on lipid metabolism and machanism in experimental hyperlipidemia rats. Methods： To feed high fat diet to set up the model of hyperlipidemia rat. The contents of TC, TG, LDL-C, HDL-C, apoA I, apoB, AST and ALT level in serum were assaged respectively in hyperlipidemia rat which had been fed resveratrol 30mg/kg bw · d and 70mg/kg bw · dig for 4 weeks respectively. In addition, liver lipid, activities of LPL and HL and fecal bile acid were assaged. Results： The TC, TG LDL-c apoB, AST and ALT in serum decreased significantly in the hyperlipidemia rats fed with the resveratrol in comparison with high lipid control group. Resveratrol significantly increased the activity of liver LPL and HL and the excretion of fecal bile acid in hyperlipidemia rats. Moreover, Resveratrol could decrease AI and increase ratioes of HDL-c/TC and apoAI/apoB. Conclusions： Resveratrol inhibited arteriosclerosis by regulation of lipid metabolism in hyperlipidemia rats.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2005年第10期228-232,共5页
Food Science
