摘要
目的:研究藻鳖软肝汤抗纤维化的作用。方法:用CC l4复合因素制备大鼠肝纤维化模型,同时用藻鳖软肝汤治疗,用生理盐水作对照,观察其对肝功能及纤维化指标的影响。结果:藻鳖软肝汤对肝纤维化大鼠,有显著降低血清透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C);明显改善肝功能的作用。结论:藻鳖软肝汤具有确切的抗纤维化作用。
Objective： To study the effects of Zao Bie Ruan Gan Tang on hepatic fibrosis. Methods： Wistar rat model of hepatic fibrosis was induced by compound factors of CCl4 and foods of high fat and high cholesterol and low protern. Meanwhile they were protected with Zao Bie Ruan Gan Tang with 0.9% NS as control group. The indexes of hepatic fibrosis and function of liver were assayed. Results： Zao Bie Ruan Gan Tang decreased the level of serum HA, Ⅳ-C, PC Ⅲ and modified function liver. Conclusion：Zao Bie Ruan Gan Tang shows definite protective and therapeutic effects on experimental hepatic fibrosis in model rats.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2005年第11期1072-1073,共2页
Lishizhen Medicine and Materia Medica Research
基金
湖北省黄石市科学技术局重点科研项目[No.黄科技发成(No.2004)4号]
关键词
肝纤维化
藻鳖软肝汤
胶原
肝功能
大鼠
Hepatic fibrosis
Zao Bie Ruan Gan Tang
Collagen
Liver function
Rats
