喉炎宁口服液治疗急慢性咽喉炎的药效学研究

Pharmacodynamic Study of Houyanning Oral Liquid on Acute and Chronic Faucitis

目的:研究喉炎宁口服液的主要药效学,为其临床应用提供理论依据。方法:采用二甲苯致小鼠耳廓肿胀、冰醋酸致小鼠腹腔毛细血管通透性亢进、小鼠棉球肉芽肿实验,考察喉炎宁的抗炎作用;采用大鼠被动皮肤过敏和2,4-二硝基氯苯致小鼠迟发性超敏反应实验,考察喉炎宁的抗过敏作用;用小鼠醋酸扭体法观察喉炎宁的镇痛作用。结果:喉炎宁口服液可明显减轻小鼠耳廓肿胀度、抑制腹腔毛细血管通透性增高、棉球肉芽组织增生;显著抑制大鼠被动皮肤过敏反应、小鼠迟发性超敏反应;减少醋酸所致小鼠扭体反应次数。结论:喉炎宁口服液有助于急、慢性咽喉炎临床症状的改善。

Objective：To study the main pharmacodynamics of Houyanning oral liquid in order to provide theoretical basis on its clinical application. Methods：Ear edema induced by dimethylbenzene, abdominal capillary permeability by acetic acid and cottonpill- implantation-induced hyperplasia in mice were used to study the anti-inflammatory effects; passive cutaneous anaphylaxis in rat and delayed type hypersensitivity induced by 2,4-nitrylchlorobenzene in mice were used to study the antiallergic effect; acetic acid-induced writhing test in mice were used to study the abirritation. Results：Houyanning oral liquid significantly suppressed xylene-induced ear edema, abdominal capillary permeability, cotton induced rat hyperplasia, and markedly inhibited passive cutaneous anaphylaxis in rat and delayed type hypersensitivity induced by 2,4-nitrylchlorobenzene in mice; the writhing times of mice induced by acetic acid decreased. Conclusion： Houyanning oral liquid is effective in clinical treatment on acute and chronic faucitis.