幽门螺杆菌与胃及食管反流性疾病关系的研究

Study on relativity between Helicobacter pylori and the gastroesophageal reflux diseases

目的探讨幽门螺杆菌与胃及食管反流性疾病之间的关系。方法对460例具有反流症状的患者进行内镜及组织学检查,并采用免疫印记法检测其血清中的幽门螺杆菌cagA、vacA抗体。结果反流性食管炎及反流性胃炎患者幽门螺杆菌的最高检出率分别为67.4%和70.2%,反流性食管炎患者cagA、vacA抗体的阳性率分别为56.3%、52.3%,而反流性胃炎患者cagA、vacA抗体的阳性率为61.9%、60.1%。结论通过对反流性食管炎及反流性胃炎患者幽门螺杆菌的检测及其抗体的检测,发现幽门螺杆菌感染可能是胃及食管反流性疾病的重要因素。

Objective In order to find the relationship between the Helicobacter pylori and gastroesophageal reflux diseases. Methods The studied population comprised 460 patients with gastroesophageal reflux diseases. They were checked by endoscopy and histology. CagA and vacA in serum were measured by immtmoblotring. Results In the patients with reflux exophagitis an reflux gastritis the determinative rates were 67.4% and 70.2%; positive rates of cagA, facA in the patients with reflux esophagitis were 56.3%, 52.3%, While in the patients with reflux gastritis were 61.9% and 60.1%. Conclusion The study suggests that the Helicobatter pylori is playing an important role in the gastroesophageal reflux dieases.