保元活血颗粒治疗老年2型糖尿病气虚血瘀证30例临床观察

Clinical Observation on 30 Cases of Senile Type 2 Diabetes with Qi-Deficiency and Blood Stasis Treated with Baoyuan Huoxue Granule

目的:探讨中药保元活血颗粒对老年2型糖尿病气虚血瘀证的作用及对血小板颗粒膜糖蛋白 p-选择素(CD62p)、纤维蛋白原受体(PAC-1)表达率的影响。方法:选择气虚血瘀证的老年2型糖尿病患者60例,随机分为两组,单纯西药对照组30例,进行常基础治疗,试验组30例,在常规降糖西药治疗的基础上加用保元活血颗粒,共治疗2个月,观察两组患者临床疗效及治疗前后 CD62p、PAC-1表达率的变化。结果:试验组显效12例(40%),有效15例(50%),无效3例(10%),总有效率90%;对照组显效3例(10%),有效12例(10%),无效15例(50%),总有效率为50%;两组总有效率比较差异有显著性(P<0.01),试验组 CD62p、PAC-1表达率较治疗前明显下降(P<0.05)。结论:保元活血颗粒能改善糖尿病患者的气虚血瘀证候,并能降低 CD62p、PAC-1的表达率。

Objective： To explore effects of Baoyuan Huoxue Granule on senile type 2 diabetes with Qi-deficiency and blood stasis, and expression rates of membrane glucoprotein selectin P（CD62p） and fibrin receptor （PAC-1） in the granule of platelet. Methods： 60 cases of senile type 2 diabetes with Qi-deficiency and blood stasis were randomly divided into two groups, a simple western medicine control group （n=30） and a test group （n=30） treated by routine western medicine and Baoyuan Huoxue Granule. The treatment was given 2 months. Their clinical therapeutic effects, and the expression rates of CD62p and PAC-1 before and after treatment were investigated. Results： In the test group, 12 cases （40%） were markedly effective, 15 cases （50%） effective, 3 cases （10%） ineffective, with an effective rate of 90% In the control group, 3 cases （10%） were markedly effective, 12 （40%） effective, 15 （50%） ineffective,the effective rate being 50%, with significant difference between the two groups in total effective rate （P〈0.01）. The expression rates of CD62p and PAC-1 in the test group after treatment decreased significantly （P〈0.01）. Conclusion： Baoyuan Huoxue Granule can improve syndromes of Qi-deficiency and blood stasis, and reduce the expression rates of CD62p and PAC-1 in the diabetic patient.