壳聚糖与N-异丙基丙烯酰胺接枝共聚凝胶的辐射合成及性能研究

PREPARATION OF HYDROGLES BASED ON POLY-N-ISOPROPYLACRYLAMIDE GRAFTED CHITOSAN VIA γ-RADIATION AND THEIR PROPERTIES

采用γ辐射技术引发壳聚糖与N异丙基丙烯酰胺进行接枝共聚,制备了温度及pH敏感水凝胶.研究了单体浓度、辐射剂量等对接枝率和接枝效率的影响,并用13CCPMASNMR和TG表征了接枝物的结构.研究结果表明,用γ射线引发壳聚糖接枝异丙基丙烯酰胺具有较高的接枝率和接枝效率,接枝的聚合物具有明显的温度及pH敏感的特点.

Thermo- and pH-sensitive hydrogels were prepared by graft copolymerization of N-isopropylacrylamide onto chitosan via γ-radiation . The effects of monomer concentration and total irradiation dose on grafting percentage and grafting efficiency were studied. The graft copolymers were characterized by 13^C CP/MAS NMR and thermogravimetric analysis. The pH-and thermo-sensitivity and swelling properties of the hydrogels were investigated. The results showed that the grafting percentage and grafting efficiency increased with the increase of monomer concentration and total irradiation dose. The highest grafting percentage is 620%, the lower critical solution temperature of this hydrogel is about 28 ℃.