期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

BCR/ABL融合基因产物P^(210)在白血病诊断中的临床意义 被引量：1

下载PDF
导出
摘要 目的:建立一种用抗ABL单克隆抗体,检测外周血P210BCR/ABL融合基因蛋白,为临床提供:特异、灵敏、快速诊断白血病的新方法。方法:采用WesternBloting印迹法检测68例符合FBA分型的白血病(CML)患者外周血细胞中P210蛋白。结果:CML患者外周血细胞中P210蛋白均为阳性。结论:外周血BCR/ABL融合基因蛋白检测法材料来源方便病人无痛苦,对提高CML患者的明确诊断和预后评估具有特异、可靠、准确、省时的临床应用价值。
作者 樊英芳
机构地区 天津市第一中心医院
出处 《陕西医学杂志》 CAS 北大核心 2005年第11期1404-1406,共3页 Shaanxi Medical Journal
关键词 白血病/免疫学 融合蛋白质类 bcr-abl/免疫学 原癌基因蛋白质P^210 BCR/ABL 白血病诊断 临床意义 基因产物 外周血细胞 Western 基因蛋白
分类号 R733.72 [医药卫生—肿瘤] R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Rowley JDA. New consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Natura, 1973; 243: 290
  • 2Guo JQ. Wang JYJ, Arlinghaus RB. Detection of BCR/ABL proteins in blood cells of benign phase chronic myelogenous leukemia patients. Cancer Research, 1991 ; 51: 3048
  • 3Guo JQ, Hirsch-Gnberg CF,Xian YM. et al. Giralt Acute lymphoid leukemia molecular phenotype in a patient with benign-phase chronic myelogenous leukemia. Hematologic Patholgy, 1993; 7: 91
  • 4Guo JQ, L Xizn YM , Lee MS, et al. BCR-ABL Protein expres sin in peripheral undergoing there.Blood , 1994 ; 83: 3629
  • 5Guo JQ, Lian J, Glassman A,et al . B Comparison of BCR/ABL protein expression and philadelphia chromosome analyses in chronic myelogenous Leukemia patients. Am J Clin Pathol, 1996; 106(4): 442
  • 6Hochhaus-A. Molecular monitoring of residuai disease in chronic myelognous leukemia patients afeer therapy. Recent Results Canaer Reseaxch, 1998;144:36

同被引文献24

  • 1de Klein A, van Kessel AG, Grosveld G, et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelo- cytic leukaemia [ J]. Nature, 1982,300 (5894) :765-767.
  • 2Bartram CR, de Klein A, Hagemeijer A, et al. Translocation of c- abl oncogene correlates with the presence of a Philadelphia chro- mosome in chronic myelocytic leukaemia [ J ]. Nature, 1983,306 (5940) :277-280.
  • 3Groffen J, Stephenson JR, Heisterkamp N, et al. Philadelphia chro- mosomal breakpoints are clustered within a limited region, bcr, on chromosome 22 [ J ]. Cell, 1984,36 ( 1 ) :93-99.
  • 4Melo JV. The diversity of BCR-ABL fusion proteins and their relation- ship to leukemia pheuotype[J]. Blood, 1996,88(7) :2375-2384.
  • 5Shaffer LG, Tommerup N. An interbational system for hunman cyto- genetic nomenclature, iscn (2005) [ M ]. Basel : Karger Basel Publi- cation ,2005:55-83.
  • 6McGrattan P, Campbell S, Cuthbert R, et al. Integration of conven- tional cytogenetics, comparative genomic hybridization and inter- phase fluorescence in situ hybridisation for the detection of genom- ic rearrangements in acute leukemia [ J ]. J Clin Pathol, 2008,61 (8) :903-908.
  • 7Virgili A, Brazma D, Reid AG, et al. FISH mapping of Philadelphia negative BCR/ABL1 positive CML [ J ]. Molecular Cytogenetics, 2008,18(1) :14.
  • 8Cremer T, Lanegent J, Brtickner A, et al. Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques : diagnosis of trisome 18 with probe LI. 84 [J]. Hum Genet,1986,74(4) :346-352.
  • 9Licher P, Cremer T, Tang JC, et al. Rapid detection of human chro- mosome 21 aberration by in situ hybridization [ J ]. Proc Nail Acad Sci U S A,1988,85(24) :9664-9668.
  • 10Landegent JE, Jansen in de Wal N, Dirks RW, et al. Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization [ J ]. Hum Genet, 1987,77 (4) :366-370.

引证文献1

二级引证文献5

陕西医学杂志
2005年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部