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原发性肝癌血管性血友病因子裂解酶的表达水平及意义 被引量：3

Clinical significance of the dysregulated expression of von Willebrand factor-cleaving protease in patients with primary hepatocarcinoma
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摘要 血管性血友病因子(von Willebrand factor, vWF)是介导癌细胞与血小板结合以及癌血栓与内皮下组织粘附的重要"桥梁"[1].
作者 高维强 周晓俊 白霞 苏健 阮长耿
机构地区 苏州大学附属第一医院 苏州大学附属第一医院普外科
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2005年第10期795-796,800,共3页 Chinese Journal of Hepatology
关键词 癌 肝细胞 肿瘤转移 甲基化 内肽酶类 血管性血友病因子 原发性肝癌 裂解酶 Willebrand PROTEASE Carcinoma, hepatocellular Metastasis, neoplasm Methylation Endopeptidases von Willebrand factor
分类号 R735.7 [医药卫生—肿瘤]
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参考文献5

  • 1Oleksowicz L, Mrowiec Z, Schwartz E, et al. Characterization of tumor-induced platelet aggregation: the role of immunorelated GP Ⅰb and GPⅡb/Ⅲa expression by MCF-7 breast cancer cells. Thromb Res, 1995, 79: 261-274.
  • 2Sadler JE. Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem, 1998, 67: 395-424.
  • 3Oleksowicz L, Bhagwati N, DeLeon-Fernandez M. Dificient activity of von Willebrand's factor-cleaving protease in patients with disseminated malignancies. Cancer Res, 1999, 59: 2244-2250.
  • 4Lee TE Bouhassira EE, Lyubsky S, et al. ADAMTS13, the von Willebrand factor cleaving metalloprotease, is expressed in the perisinusoidal cells of the liver. Blood, 2002, 100(Suppl.1): 497a.
  • 5Mannucci PM, Canciani MT, Forza I, et al. Changes in health and disease of the metalloprotease that cleaves von Willebrand factor. Blood,2001, 98: 2730-2735.

同被引文献9

  • 1Fukikawa K, Suzuki H, McMullen B, et al. Purification of human yon Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family[J]. Blood, 2001,98(6) :1662-1666.
  • 2Yoo G, Blomback M, Gustafsson S, et al. Decreased levels of yon willebrand factor-cleaning protease in coronary heart disease and thrombotic thrombocytopenic purpure: study of a simplified method for assaying the enzyme activity based on ristocetin-induced platelet aggregation[J]. Brit J Haematol, 2003,121(1) :123-129.
  • 3Rieger M, Marmucci PM, Kremer Hovinga JA, et al. ADAMTS13 autoantibodies in patients with thrombotic mieroangiopathies and other immunomediated diseases [J].Blood, 2005,106(4) : 1262-1267.
  • 4Mannucci PM, Vanoli M, Forza I, et al. Von Willebrand factor-cleaving protease (ADAMTS13) in 123 patients with connective tissue disease(systemic lupus erythematosus and systemic sclerosis) [J]. Thrombosis, 2003,188(8) :914-917.
  • 5Weening J J, D'Agati VD, Schwartz MM, et al. The classification of glomerulone-phritis in systemic lupus erythematosus revisited[J]. Kidney Int, 2004,15 (2) : 241-250.
  • 6Rick ME, Molls S, Taylor MA. Clinical use of rapid collagen binding assay for yon Willebrand factor cleaving protease in patients with thrombotic thrombo-cytopenic purpura[J].Thromb Haemost, 2002,88 (4) .. 598-604.
  • 7Gerritsen HE,Robles R, Lammle B, et al. Partial amino acid sequence of purfied von willebrand factor-cleaving protease [J].Blood,2001,98(6) : 1654-1661.
  • 8Levy GG, Nichols WC, Lian EC, et al. Mutation in a member of the ADAMTS13 gene family cause thrombotic thromobeytopenic purpura[J]. Nature,2001,413 (6855) : 488-494.
  • 9Mannucci PM, Canciani MT, Forza I, et al. Changes in health and disease of the metalloprotease that cleaves von willebrand factor[J]. Blood,2001,98(9):2730-2735.

引证文献3

二级引证文献8

中华肝脏病杂志
2005年 第10期

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