人舌癌组织中转录因子p65的表达及意义

High Expression of p65 Transcription Factor and Its Significance in Tongue Carcinoma

目的研究p65在舌癌组织中的表达及其与舌癌转移、预后的关系。方法应用免疫组化方法检测50例舌癌患者的癌组织中p65的表达,并对其与患者临床病理特征的关系进行分析。结果p65阳性表达率为64%;其阳性表达率在不同TNM分期之间有统计学差异(P<0.05),分期越高p65表达率越高;p65的阳性表达率与淋巴结转移有关,有淋巴结转移者p65阳性率高(P<0.05);但不同病理分级间p65的表达无统计学差异(P>0.05)。Kap-lan_Meier生存曲线显示p65阳性表达组、阴性表达组的5年生存率分别为59.3%和88.9%,两组之间有统计学差异(P<0.05)。结论p65异常表达在判断舌癌转移和患者预后方面有重要意义。

Objective To examine the correlation between p65 expression and the metastasis and prognosis in tongue carcinoma. Methods The immunohistochemical expression of p65 was examined in 50 cases of tongue carcinoma, and the clinical and histopathologic records were retrospectively analyzed. Results Overexpression of p65 in cytoplasma and nucleus was found in 64% cases of tongue carcinoma. There was significant difference of p65 expression among different TNM stages, and the higher expression rate of p65 was found in higher stages. Overexpression of p65 was also related to lymph node metastasis. Significantly greater increase in expression levels of p65 was found in the metastatic cases （ n = 22） compared to the nonmetastatic cases （ n = 10）. However, there was no significant difference of p65 expression among different histopatholngic grading. The 5-year survival rate of p65 positive and negative group was 59.3% and 88.9% respectively, and there was significant difference in Kaplan-Meier survival curve （x^2 = 5.6, P 〈 0.05 ）. Conclusion The results suggest that the expression of p65 was important to predict the metastasis and prognosis in tongue carcinoma.