杜仲全叶深度综合利用技术路线研究

Technological route of comprehensive utilization of leaves of Eucommia ulmoids.

杜仲叶含有多种类型的化合物,其性质差异很大(从极性到非极性);同一类型化合物中异构体多,其差异性又很小,难以分离.其中一些化合物热敏感性强,又极易氧化、异构、分解.该文依据各化合物的理化性质及差异,采用逆流浸提罐组液固浸提原理,变温、变溶剂和浓度、变时间等的分段处理技术,同步分离制取有效组分11种,即β胡萝卜素、叶绿素铜钠、松脂醇二葡萄糖甙、绿原酸、桃叶珊瑚甙、二氢黄酮、查耳酮、黄酮醇、酸多糖、β谷甾醇、杜仲胶等.除杜仲胶外,其余均为药用活性成分.全叶总抽出物得率为25%～27.5%,有效活性成分得率为11.19%～13.56%.

The leaf of Eucommia ulmoids contains varieties of compounds whose properties are quite different, ranging from polarity to non-polarity. With kinds of isomers which are slightly different in nature, the same type of compounds are difficult to separate. Some compounds are strongly sensitive to heat or easy to oxidize, isomerize and decompose. On the basis of physicochemical properties and differences, countercurrent leaching is adopted and parameters such as temperature, solvent and its concentration, time, etc. are changed according to the demand. The total recovery ratio is 25 %-27.5 % and 11 compounds are isolated, they are β- carotene, sodium copper chlorophyllin, pinoresinol diglucoside, chlorogenic acid, aucubin, dihydroflavonoids, chalcone, flavonol, acid polysaccharides, β-Sitosteml and gutta percha. The yield of drug active compounds is 11.19 %- 13.56 %.