GPDA、CA72-4、CA50联检在胃癌诊断中的价值

The Value of Combined Detection of GPDA,CA72-4 and CA50 in Diagnosis of Gastric Cancer

目的探讨GPDA、CA724、CA50三项联检对胃癌的临床诊断价值。方法采用电化学发光免疫分析、放射免疫法及全自动生化分析仪等技术,对125例胃癌、77例胃良性疾病、50例正常健康人血清进行GPDA、CA724、CA50三项检测。结果胃癌组GPDA、CA724、CA50敏感性分别为62.4%、68.0%,54.4%;特异性分别为97.6%、97.6%、98.4%。三项联检敏感性提高到89.6%,与单检比较有统计学意义(P<0.05);同时特异性并未明显降低,仍有93.7%。结论GPDA、CA724、CA50可作为临床诊断胃癌的肿瘤标志物,三项联检可明显提高阳性检出率。

Objective To study the diagnostic value of Glycyl Proline Dipeptidyl Aminopeptidase （GPDA）, CA72-4 and CAS0 in gastric cancer. Metlmds Serum levels of GPDA, CA72-4 and CAS0 in 125 patients with gastric cancer, 77 patients with benign gastric tumor and 50 normal controls were measured by electro-chemilu minescence immuno-assay （ECLIA） and radioimmunoassay and automatic biochemical analyzer. Results Sensitivities of GPDA, CA72 4 and CAS0 in gastric cancer group were 62. 4%, 68. 0% and 54. 4%, respectively, and the specificities were 97. 6%, 97. 6% and 98. 4%, respectively. The sensitivity of combined detection of three tumor markers increased to 89. 6%, and the specificity was 93. 7%. Conclusion GPDA, CA72-4 and CA50 can serve as the serum tumor marker in clinical diagnosis of gastric cancer. Combined detection of three kinds of serum tumor makers increases the detective positive rate.