前列腺癌AR表达与细胞增殖的关系

Relationship between proliferation of prostate cancer cells and androgen receptor expression

目的探讨113例人前列腺癌雄激素受体(AR)与增殖相关因子表达的相关性。方法应用免疫组化标记AR、细胞增殖相关因子(K i67、PCNA)。EGFR及核仁组成区AgNOR染色,结合光镜、电镜观察及图像分析等方法,研究AR表达与PCa增殖的相互关系。结果前列腺癌AR(-)组细胞增殖作用较AR(+)组明显增强。结论AR突变,造成PCa细胞的无限增殖能力增强,细胞生长迅速,异质性更明显,可能是PCa难于治疗的原因之一。

Objective To explore the relationship between proliferation activity-related factors and androgen receptor （AR） expression in 113 cases of human prostate cancer （PCa）. Methods AR and the proliferation activity-related factors （PCNA, Ki67, EGFR） in PCa were detected by immunohistochemistry and light/ electron microscopy. Results Cell proliferation in AR-negative groups of PCa was significantly stronger than in AR-positive groups. Conclusion AR aberrant expression may promote proliferative ability of PCa, cell growth and heterogeneity significantly, which may be one of reasons that PCa is difficult to be cured.