儿童皮肤非何杰金淋巴瘤与EB病毒的相关性研究

The Relationship Between Cutaneous Non-Hodgkin's Lymphoma and Epstein-Barr Virus Infection in Childhood

目的研究EB病毒与儿童皮肤非何杰金淋巴瘤(nonhodgkin’lymphoma,NHL)发病的关系。方法采用原位杂交法对36例儿童皮肤NHL的标本进行EB病毒编码的小分子寡核苷酸(Epstein-Barr viralencoded RNA,EBER)检测。结果36例中EBER阳性7例(19.4%),其中皮下脂膜炎样T细胞淋巴瘤(subcutaneous panniculitis-like T-celllym-phoma,SPTCL)5例;外周T细胞淋巴瘤、Burkitt’s瘤各1例;CD30+间变型大细胞淋巴瘤、T淋巴母细胞性淋巴瘤均未见阳性表达。结论EB病毒感染与皮下脂膜炎样T细胞淋巴瘤可能有关,与T淋巴母细胞性淋巴瘤、CD30+间变型大细胞淋巴瘤关系不明显,其与累及皮肤的Burkitt’淋巴瘤的关系有待进一步证实。

Objective To study the relationship between cutaneous non-hodgkin＇s lymphoma and epstein-barr virus infection in childhood . Methods The samples of 36 patients with cutaneous NHL were used to detect the EBV-encoded RNA （EBER） by in situ hybridization （ISH）. Results Seven of 36 （ 19, 4% ） samples showed positive signals including five of thirteen subcutaneous panniculitis-like T-cell lymphoma （SPTCL） ;one of four unspecified peripheral T-cell lymphoma;one of two Burkitt＇s lymphoma; none of lymphoblastic lymphoma and CD30^＋ cutaneous anaplastic large cell lymphoma was positive. Conclusion EBV infection might be related to SPTCI, and might not be related to lymphoblastic lymphoma and CD30^＋ cutaneous anaplastic large cell lymphoma, the role of EBV in the pathogenesis of Burkitt＇s lymphoma needs further invest;gation .