异维A酸治疗中度寻常痤疮临床疗效观察

Treatment of medium degree acne vulgaris with isotretinoin

目的:评价异维A酸治疗中度痤疮的疗效和安全性。方法:采用随机、阳性药物平行对照的临床试验。试验组患者每日服用异维A酸(泰尔丝);对照组患者每日服用维胺酯,两组患者均治疗6周。治疗2、4、6周,对两组痤疮患者的粉刺、丘疹、脓疱、结节囊肿、皮脂溢出等评分比较。结果:试验组皮损的总评分差值从(0.2166±0.1291)分增至(6.2469±1.1826)分,对照组则从(0.1290±0.3191)分增至(5.6297±1.4489)分,两组间痤疮评分差值比较,差异有显著性。治疗结束时,试验组痊愈率和有效率分别为58.18%和100.00%,对照组分别为22.41%和82.75%,二组间疗效比较差异有显著性。试验组有23例患者出现局部不良反应,对照组有31例患者出现局部不良反应。结论:异维A酸治疗中度寻常痤疮疗效好于维胺酯。

Objective： To evaluate the clinical efficacy and safety of isotretinoin in the treatment of medium degree acn~： vulgaris. Methods： A randomized parallel controlled clinical study was performed in 122 patients with medium degree ache vulgaris. The test group was treated with isotretinoin （lO mg bid, for 6 weeks） and the others, as control, were treated with viaminate （50 mg bid, for 6 weeks）. The change-in-ache scores （including comedo, papules, pustules, cyst and sebum excretion） were counted in the end of every two weeks. Results： The change-in-acne scores in the isotretinoin group increased from （0.216 6±0.129 l） to （6.246 9±1.182 6） and that in the viaminate group increased from （0.1290±0.319 l） to （5.6297±1.4489）. There was significant difference in the reduction of the change-in-acne scores between the two groups. After 6-week-treatment the cure rate and the response rate were 58.18% and 100.00% respectively in the isotretinoin group. Otherwise, in the control group, they are 22.41% and 82.75% respectively, which was statistically less than those in the isotretinoin group. There were 23 patients with the local adverse reactions in the isotretinoin group and 31 patients with such reactions in the control group. There was no statistical difference in the adverse reactions between the two groups （P=0.2076）. Conclusion： Isotretinoin is more effective in the treatment of medium degree ache vulgaris.