巩膜扩张带术对兔眼调节及眼压的影响

Influence of scleral expansion band surgery on accomodation and intraocular pressure in rabbit

目的评价巩膜扩张带术(SEB)对药物诱导的兔眼调节及眼压的影响,同时观察前巩膜梭形切除术(ASS)对药物诱导调节的作用。方法自身配对实验设计,10只新西兰白兔,随机一眼做SEB,另一眼做ASS。术前及术后1个月分别测定生理状态下的屈光度、眼压以及点毛果云香碱滴眼液之后的屈光度。屈光度中的散光值折合球镜的一半计算。结果SEB前后生理状态下的屈光度差异无显著意义(2.71±1.14,2.44±1.37),而点毛果云香碱滴眼液之后的屈光度在手术前后存在显著差异(1.42±1.47,-0.33±2.00),术后屈光力平均增加1.75D;手术前后的眼压差异无显著意义;ASS前后的生理屈光度差异无显著意义(2.56±1.22,2.68±1.10),点毛果云香碱滴眼液之后的屈光度差异亦无显著意义(0.76±1.49,1.08±1.35)。结论SEB在兔眼中可使药物诱导的调节力增强,对眼压无明显影响;ASS对药物诱导的兔眼调节力无显著作用。

Objective To investigate the influence of scleral expansion band surgery on rabbit drug-induced accomodation and intraocular pressure anti evaluated the accomodation caused by anterior shuttle-like sclerectomy. Methods Scleral expansion hand （SEB） surgery was performed on lateral eyes of 10 New Zealand rabbits and anterior shuttle-like sclerectomy （ASS） on the fellow eyes. Pilocarpine drops was used in each eye twice a day at a 10-minute interval before and after operation. Refraction and intraocular pressure （IOP） under physiological status and after administering pilocarpine were measured preoperatively and 1 month postoperatively. The astigmatism value was processed as half of the spherical in refraction recording. Results There was no significant difference in refraction under physiological status before and after SEB（2.71 ± 1. 14 vs 2.44 ± 1. 37） ,but a significantly statistical difference was found in refraction after administering piloearpine before and after operation （ 1. 42 ± 1. 47 vs - 0. 33 ± 2.00） with a mean increase of I. 75 D after surgery. There was no significant differences in refraction under the physiological status before and after ASS（2.56 ± 1. 22 vs 2.68 ± 1. 10） as well as after administering pilocarpine before and after ASS （ 0. 76 ± 1. 49 vs 1. 08 ± 1.35 ）. However, whatever ASS or SEB, the refraction showed a statistical increase following the application of pilocarpine in both before and after operations. The astigmatism value had a significant decrease after SEB （0. 89 ± 0.45） in comparison with that of before SEB（ 1. 91 ± 0.86） and no statistical difference in IOP between them（ P 〉 0. 05）. Conclusion SEB can increase the drug-induced accomodation in rabbits, but there was no remarkable influence on IOP. ASS had no significant effect on accomodation of the rabbits.