摘要
在乙酸乙酯介质中,2,6-二氯-4-硝基苯胺(DCNA)经重氮化和还原脱氨基“一锅煮”方法合成出3,5-二氯硝基苯。乙酸乙酯不仅作两相反应的溶剂,而且也提供还原剂乙醇。反应过程中没有棕色的二氧化氮废气产生,酸耗量少,且无副产物如醚类生成。对反应中亚硝酸钠用量、硫酸浓度及用量、乙酸乙酯用量、反应温度等因素进行了研究。
In ethyl acetate media 2,6-dichloro-4-nitroaniline reacted to give 3,5-dichloronitrobenzene through diazotization and reductive deamination in one-pot. Ethyl acetate displayed not only as a solvent for two-phase reaction, but also as a pro-reducing agent. The process was satisfactory with little pollution of waste acid and waste gas and had no by-products（e.g, ether）.The factors including amounts of sodium nitrite, sulfuric acid and ethyl acetate, and reaction temperature were investigated.
出处
《化学试剂》
CAS
CSCD
北大核心
2005年第10期625-626,共2页
Chemical Reagents
关键词
3
5-二氯硝基苯
乙酸乙酯
脱氨基
两相反应
3,5-dichloronitrobenzene
ethyl acetate
deamination
two-phase reaction
