间二氨基苯偶酰的合成

Synthesis of m-diaminobenzil

研究了以苯甲醛作为原料,经过自身缩合、氧化、硝化和选择性还原合成了标题化合物。探讨了影响产率的诸因素,并对产物结构进行了表征。

m-Diaminobenzil was prepared via self-condensation, oxidation, nitration, selective reduction from benzaldehyde, the characterization of the product has been investigated by MS, IR, ^1 HNMR. The sorting of selective reduction reagent and the optimum of reduction process conditions have been researched. The optimum conditions were determined as follows：the molar ratio of dinitrobenzil to stannous chloride was 1：9, the reaction temperature was 115℃, the reaction time was 2h. Under these conditions the yield of product was 80.5 %, the purity was 97 %.