冷冻和缺氧对大鼠血清肌酸激酶活性的影响

Effects of Freezing and Hypoxia on Serum Creatine Kinase Activity in Rats.

为探讨冷冻和缺氧对大鼠机体的影响，本文以血清肌酸激酶（ＣＫ）活性为指标，观察了冷习服、缺氧习服及低氧冷暴露４周的Ｗｉｓｔａｒ大鼠，在常氧和模拟６０００ｍ低氧条件下实验性冻伤后组织损伤的严重程度。结果表明，冷习服大鼠抗冻能力增强，损伤减轻；缺氧习服大鼠抗冻能力明显减弱，损伤加重，即缺氧与寒冷之间为负交叉习服。低氧冷暴露４周大鼠冻后血清ＣＫ活性变化与缺氧习服大鼠基本一致，与冷习服大鼠明显不同。表明在本实验条件下，低氧冷暴露过程中缺氧对机体的影响比低温更明显，其机理有待于进一步研究。

Serum creatine kinase (CK) activity after cold exposure in rats acclimated to cold,hypoxia, or combined factors (both cold and hypoxia) were observed under normoxie and hypoxic condition in order to study the degrees of damage to the tissues. The results showed that resistance to frostbite increased in rats acclimated to cold; resistance to frostbite decreased markedly in rats acclimated to hypoxia ,i.e. negative cross-acclimation exists between hypoxia and cold. The changes in serum CK activity in rats exposed to both cold and hypoxia for 4 weeks were essentially the same as those in hypoxia-acclimated rats,and were different significantly from those in cold-acclimated rats. It indicates that the effects of hypoxic exposure were stronger than those of cold exposure, its mechanism remains an area for further study.