静脉吸毒人群HIV阳转率与队列保持影响因素

HIV incidence and factors associated with retention in a 12-month follow-up study of injection drug users in Xichang County

目的了解静脉吸毒人群HIV血清抗体阳转率和队列本底的社会人口学和高危行为特征以及6个月随访情况与队列12个月保持率的关系.方法于2002年11月,在四川省西昌市从社区筛查HIV抗体阴性的静脉吸毒人群前瞻性研究队列333人.在队列每6个月随访时进行HIV抗体检测来估算HIV血清抗体阳转率和分析队列本底的社会人口学和高危行为特征以及6个月随访情况与队列12个月保持率的关系.结果静脉吸毒人群队列12个月的HIV血清抗体阳转率为3.17×10-2人年(95%CI=0.98～5.37)和保持率为70.3%.在多因素Logistic回归分析中,与队列12个月保持率差异有统计学意义的变量为6个月能随访到(OR=8.74,95%CI=4.95～15.41;P＜0.0001)和彝族(OR=0.50,95%CI=0.28～0.87;P＜0.0151).未见静脉吸毒人群队列本底的HIV高危行为因素与队列12个月保持率的关系差异有统计学意义.结论静脉吸毒人群HIV血清抗体阳转率彝族和6个月未随访到的吸毒人群队列12个月的保持率低.

Objective To understand HIV incidence and retention by subject＇s baseline sociodemographic and behavioral characteristics in a 12-month follow-up study of injection drug users. Methods During November 2002, a community-based baseline survey was conducted to recruit 333HIV sero-negative injection drug users（IDUs） for a prospective cohort study in Xichang County of Sichuan Province, China. Results During the first 12-month follow-up period, HIV incidence was 3.17 per 100 person-years [95 % confidence interval（CI）： 0.98, 5.37]. The retention rate at the 12-month follow-up visit was 70.3 %. In a multiple logistic regression model, appearing at 6-month follow-up visit （ OR = 8.74, 95 % CI 4.95～15.41 ; P 〈 0.0001 ） and Yi ethnlcity （ OR = 0.50, 95 % CI 0.28 -- 0.87 ; P 〈 0.0151 ） were independently associated with retention in a 12 - month follow - up study of injection drug users. No drug using and sexual behaviors were found to be associated with retention at the 12 - month follow - up visit. Conclusion There is a high HIV incidence among IDUs in Xichang County of Sichuan province, China; Yi ethnicity has a lower retention rate and appearing at 6 - month follow - up visit may predict long - term retention rate in IDUs cohort, respectively.