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烟酰胺对紫外线诱发DNA损伤的保护作用 被引量：1

Protective effect of nicotinamide on ultraviolet radiation-induced DNA damage
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摘要 目的探讨烟酰胺对紫外线照射诱发DNA损伤的保护作用.方法提取人外周血中的淋巴细胞,采用单细胞凝胶电泳法观察经不同浓度烟酰胺处理并用紫外线照射所诱发的淋巴细胞DNA损伤状况.结果随着紫外线照射剂量的增加,淋巴细胞的DNA损伤程度逐渐加重;在0.01～0.1 mmol/L浓度范围内,外源性烟酰胺可明显减轻紫外线照射所诱发的DNA损伤,其保护作用具有一定的剂量依赖趋势.结论适宜浓度的烟酰胺是抗紫外线照射诱发DNA损伤的拮抗剂. Objective To investigate the protective effect of nicotinamide on UVR-induced DNA damage. Methods After extracting human peripheral blood lymphocytes and treating them with nicotinamide as well as ultraviolet radiation, the damaged degree of lymphocytic DNA was examined with single cell gel electrophoresis. Results With the UVR dose increasing, the damage degree of lymphocytic DNA increased gradually. After treating with nicotinamide within 0.01～0.1 mmol/L, UVR-induced DNA damage was reduced. The protective effect of nicotinamide showed dose-dependent manner. Conclusion nicotinamide is a perfect antagonist to UVR-induced DNA damage within fitting concentration.
作者 李晶 程梅 刘扬 宁玉英
机构地区 中国医科大学公共卫生学院 辽宁省卫生监督所
出处 《中国公共卫生》 CAS CSCD 北大核心 2005年第11期1364-1365,共2页 Chinese Journal of Public Health
关键词 烟酰胺 紫外线照射 DNA损伤 nicotinamide UVR DNA damage
分类号 R122.4 [医药卫生—环境卫生学]
  • 相关文献

参考文献9

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共引文献12

同被引文献8

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  • 8李沛波,关永源,贺华,丘钦英,周家国,周园,史小莲.中波段紫外线对角质形成细胞凋亡的诱导和钙信号的影响[J].中国药理学通报,2004,20(4):398-402. 被引量：8

引证文献1

中国公共卫生
2005年 第11期

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