糖和H_8-BINOL衍生的单齿亚磷酸酯配体的合成及其Rh催化α-脱氢氨基酸不对称氢化反应的研究

The Synthesis of Monodentate Phosphite Ligands Derived from Carbohydrates and H_8-BINOL and Their Application in Rh-catalyzed Asymmetric Hydrogenation of α-Dehydroamino Acids

由单糖(如果糖、葡萄糖和甘露醇)和H8-2,2'-联萘二酚出发设计和合成了的六个手性单齿亚磷酸酯配体,研究了其铑配合物催化α-脱氢氨基酸甲酯的不对称氢化反应,在1%mol催化剂量和0.12MPaH2下,产物的对映选择性最高达到90.6%e.e.

Six monodentate phosphite ligands derived from carbohydrates （for example： fructose, glucose and mannitol） and H8-BINOL were synthesined and successfully employed in Rh-catalyzed asymmetric hydrogenation of methyl α-dehydroamino acids. Up to 90.6% ee was obtained with 1% mol of catalyst and 0.12 MPa hydrogen pressure.