金力源胶囊对大鼠血脂调控作用的研究

Study of the blood lipid regulation of Jinliyuan capsules on experimental hyperlipidemia rates

目的:观察金力源胶囊对高脂血症大鼠血脂的调节作用,为开发防治高脂血症的中药提供实验依据。方法:W istar大鼠60只按体重随机分为普通饲料组、高脂模型组,按剂量金力源分别为高剂量组(4g/kg)、中剂量组(2g/kg)、低剂量组(0.8g/kg)、和力平之对照组。于实验后第12周测定大鼠血清总胆固醇(Ch)、甘油三脂(Tg)及高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果:与高血脂模型组相比,金力源各组大鼠体重和肝体重比例均显著降低(P<0.05),血清Ch,Tg,LDL-C含量均显著降低(P<0.05),HDL-C含量无显著变化。结论:金力源对实验性高血脂大鼠有明显的降血脂效应,使实验大鼠的Ch、Tg和LDL-C显著降低,而且能显著减轻实验大鼠的体重和肝体重比例。

Objective：To study the anti-hyperlipidemia effect of Jinliyuan capsules （JLY） on experimental hyperlipidemia rates. Methods：60 male Wistar rats were randomly divided into six groups. They were fed with normal diet, high lipid diet, high lipid diet with different concentration JLY （4g/kg, 2g/kg, 0.8g/kg）, high lipid diet with Lipingzhi capsules, respectively. The body weight were measured weekly. After 12 weeks, the serum Ch, Tg, HDL-C, LDL-C and liver weight were measured. Results：The data showed that JLY could significantly lower body weight, the ratio of liver weight/body weight and serum Ch, Tg, LDL-C level of experimental hyperlipidemia rates （ P 〈 0.05 ）, but has no significant effect on serum HDL-C. Conclusion： JLY has potential regulation function on lipid metabolism.