摘要
目的:观察金力源胶囊对高脂血症大鼠血脂的调节作用,为开发防治高脂血症的中药提供实验依据。方法:W istar大鼠60只按体重随机分为普通饲料组、高脂模型组,按剂量金力源分别为高剂量组(4g/kg)、中剂量组(2g/kg)、低剂量组(0.8g/kg)、和力平之对照组。于实验后第12周测定大鼠血清总胆固醇(Ch)、甘油三脂(Tg)及高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果:与高血脂模型组相比,金力源各组大鼠体重和肝体重比例均显著降低(P<0.05),血清Ch,Tg,LDL-C含量均显著降低(P<0.05),HDL-C含量无显著变化。结论:金力源对实验性高血脂大鼠有明显的降血脂效应,使实验大鼠的Ch、Tg和LDL-C显著降低,而且能显著减轻实验大鼠的体重和肝体重比例。
Objective:To study the anti-hyperlipidemia effect of Jinliyuan capsules (JLY) on experimental hyperlipidemia rates. Methods:60 male Wistar rats were randomly divided into six groups. They were fed with normal diet, high lipid diet, high lipid diet with different concentration JLY (4g/kg, 2g/kg, 0.8g/kg), high lipid diet with Lipingzhi capsules, respectively. The body weight were measured weekly. After 12 weeks, the serum Ch, Tg, HDL-C, LDL-C and liver weight were measured. Results:The data showed that JLY could significantly lower body weight, the ratio of liver weight/body weight and serum Ch, Tg, LDL-C level of experimental hyperlipidemia rates ( P 〈 0.05 ), but has no significant effect on serum HDL-C. Conclusion: JLY has potential regulation function on lipid metabolism.
出处
《军医进修学院学报》
CAS
北大核心
2005年第5期358-359,共2页
Academic Journal of Pla Postgraduate Medical School
基金
解放军总医院成果转化基金资助项目(03YC09)