奥扎格雷纳治疗冠心病的临床研究

Clinical research about Sodium Ozagrel for injection used in coronary atherosclerotic heart disease

目的:观察奥扎格雷纳(丹奥)治疗冠心病的临床疗效及对甲襞微循环和血液流变学变化的影响。方法:选择符合WHO冠心病诊断标准的患者192例确定为研究对象,随机分为丹奥治疗组(A组)112例和对照组(B组)80例。两组患者分别以治疗前后观察症状改善情况、心电图变化、甲襞微循环和血液流变学变化。结果:治疗组用药后临床疗效总有效率达88.48%、心电图变化总有效率达83.93%,与对照组比较(P<0.01)。甲襞微循环各项指标和血液流变学变化均优于对照组(P<0.01)。结论:丹奥治疗冠心病疗效显著,临床症状明显改善,心电图缺血变化好转,甲襞微循环和血液流变学指标明显改善。

Objective：To observe the clinical result about Sodium Ozagrel for injection used in coronary atherosclerotic heart disease and the effect to nail mircrocirculation and hemorrheology. Methods ：192 cases who match coronary atherosclerotic heart disease diagnosis standard of WHO were establish for research object. 112 cases were allotted in cure group （A group） and 80 cases in matched control group （B group） randomly. The improvement of symptom, variety of electrocardiogram, nail mircrocirculation and hemorrheology were observed in two groups before and after treatment. Results：The total efficient is 88.4% in a group after treatment; the total efficient is 83.93% about variety of electrocardiogram（P 〈 0.01 ）; the nail mircrocirculation and hemorrheology are all better than B group. Conclusion：The clinical result is obvious about Sodium Ozagrel for injection used in coronary atherosclerotic heart disease; The improvement of clinical symptom is obvious; the variety of myocardial ischemia is better; the sign of nail mircrocirculation and hemorrheology improve obviously.