凝血因子Ⅴ基因Leiden突变与反复自然流产的关系

Association of Factor Ⅴ Gene Polymorphism with Susceptibility to Recurrent Spontaneous Abortion

目的:探讨凝血因子Ⅴ基因Le iden突变在中国广东地区反复自然流产患者遗传发生学中的作用。方法:聚合酶链反应-限制性片断长度多态技术检测50例反复自然流产患者(实验组)和50例正常妇女(对照组)的凝血因子Ⅴ基因Le iden突变。结果:习惯性流产组和对照组均无凝血因子Ⅴ基因Le iden突变的存在。结论:凝血因子Ⅴ基因Le iden突变与中国广东地区妇女反复自然流产的遗传易感性无关。

Objective： To explore the association of coagulation factor V （FV） gene polymorphism with susceptibility to recurrent spontaneous abortion （RSA） in Guangdong women. Methods： 50 patients with RSA （ RSA group ） and 50 normal females （control group） were included and the FV site single nucleotide polymorphism at Leiden was detected with polymerase chain reaction- restriction fragment length polymorphism （PCR-RFLP）. Results： No gene nmtation was found in either RSA women or control group. Conclusions： In Guangdong women, gene polymorphism are not associated with the occurrence of RSA.