妊娠期肝内胆汁淤积症76例分析

Clinical Analysis of Patients with Intrahepatic Cholestasis of Pregnancy

目的:探讨妊娠期肝内胆汁淤积征(ICP)对母儿的不良影响。方法:对2003年1月至2003年12月间76例ICP患者与108例对照组进行回顾性分析。结果:76例ICP患者中,早产率18.42%,产后出血率15.78%,新生儿窒息率15.78%,胎儿窘迫率36.84%,足月小样儿发生率13.16%,死胎0例,死产1例。与对照组比较,除死胎、死产外,差异有显著性。胆汁酸水平的高低影响围产儿的预后及母亲并发症。结论:ICP易引起死胎、死产、早产、胎儿窘迫及母亲产后出血及造成低体重儿。胆汁酸水平愈高,围产儿预后越差和母亲产后出血发生率越高。

Objective： To investigate the effect of intraheptic cholestasis of pregnancy （ICP） on meter and fetus. Method： A contrast analysis was carried out by 76 cases of ICP from Jan ,2003 to Dec ,2003. The contrast group was 108 cases. Result： In 76 cases of ICP ,the premature birth rate was 18.42%, the postpartum hemorrhage rate was 15.78% ,the neonate asphyxia rate was 15.78%, the fetal distress rate was 36. 84% ,IUGR rate was 13.16% ,fetal death was zero, stillbirth was 1 case. In comparation with the contrast group, there were significant differences except for fetal death and stillbirth. The level of TBA affects fetal well being and maternal complications. Conclusion： Patients with ICP tend to fetal death, stillbirth, fetal distress and postpartum hemorrhage, newborn infants of low birth weight. The higher the level of TBA , the worse fetal well being , and the more materal postpartum hemorrhage occurs.