2型糖尿病伴脂肪肝与瘦素及血脂代谢的相关分析

Leptin and lipid metabolism in type 2 diabetic patients with fatty liver disease

目的探讨2型糖尿病(DM)伴脂肪肝与瘦素及脂代谢紊乱的相关性。方法随机选择我院内分泌科200例2型糖尿病患者,其中合并脂肪肝组89例,非脂肪肝组111例,对其进行有关临床、病史、生化指标、瘦素、C肽与肝脏B超检查。结果2型糖尿病伴脂肪肝组与不伴脂肪肝组比较体质量指数(BMI)(27.68±4.00)vs(24.72±3.07)kg/m2、甘油三酯(TG)(2.88±3.19)mmol/Lvs(1.74±1.18)mmol/L、1小时C肽(4.23±2.87)μg/Lvs(2.32±1.97)μg/L、2小时C肽(4.43±2.93)μg/Lvs(2.71±1.54)μg/L、瘦素(13.08±8.88)μg/Lvs(8.63±5.45)μg/L,水平明显增高。Logistic逐步回归分析显示1小时C肽、瘦素、甘油三酯水平与脂肪肝的发生呈正相关(r=0.005、0.002、0.040)。结论TG、1小时C肽、瘦素是影响2型糖尿病脂肪肝发生的主要影响因素。

Objevtive To study leptin and lipid metabolism in type 2 diabetic patients with fatty liver. Methods Selected 200 inpatients and outpatients in endocrinology department of Yuhuangding Hospital randomly of which 89 patients were with fatty liver, 111 patients without fatty liver, a set of examinations including clinic history, biochemical test, leptin, C-peptide and liver ultrasound were carried out. Results Body mass index（BMI） （27.68± 4.00） kg/m±vs （24.72 ± 3.07） kg/m^2 , triglyceride （TG） （2.88 ± 3.19） mmol/L vs （1.74 ± 1.18） mmol/L, 1 h C- peptide （4.23± 2.87） μg/L vs （2.32 ± 1.97） μg/L, 2 h C-peptide （4.43 ± 2.93） μg/L vs （2.71 ± 1.54） μg/L and leptin （13.08±8.88） μg/L vs （8.63±5.45） μg/L in type 2 diabetes with fatty liver group were higher than in type 2 diabetes without fatty liver group. The result of logistic regression indicates that 1 h C-peptide, leptin, and TG are associative with fatty liver （ r = 0. 005,0. 002, 0. 040）. Conclusion TG, 1 h C-peptide and leptin are important associative factors in the patients of type 2 diabetes with fatty liver disease.