骨疏康颗粒防治骨质疏松症的Meta分析

Meta analysis on the prevention and treatment of osteoporosis with Gushukang granules

目的：分析骨疏康对何种类型骨质疏松症的疗效更为可靠的文献报道，进而探讨其潜在的药理作用。 方法：收集2003-10以前近8年的骨质疏松会议汇编以及文献，检索出符合入选标准的随机对照临床试验8项，通过1085例患者应用骨疏康后疗效的汇总，对其中1型和2型骨质疏松症构成比例进行Meta分析。先将各临床实验中相关因素相同的性别组和年龄组、骨密度测定部位及方法、显效率、疗程，以及合并骨折情况等的实际病例数进行归纳整合并计算该类病例占全部病例的百分率，根据病例样本数的多少和所占比例的高低来评价骨疏康对何种类型骨质疏松症的疗效更为可靠。如果组内病例数少于54，即占全部病例的百分率小于5％，则不能认为其疗效可靠。 结果：①骨疏康治疗组的临床疗效显著高于其他对照组，显效率均值超过70％。②病例构成主要来自女性的1型患者，2型患者所占比例小于5％。 结论：骨疏康对女性绝经后的1型骨质疏松症患者，包括合并轻度骨折的患者可有显著临床疗效，对男性患者也有疗效。骨疏康与钙剂的协同有增效作用。骨疏康对老年性的2型骨质疏松症患者疗效不能肯定，相关结论尚须进一步研究。骨疏康能否改善骨体积密度难以定论，同样须进一步研究。

AIM：To analyze the reports about Gusukang has more reliable curative effeet on which type of osteoporosis, and investigate its potential pharmacological action. METHODS：The conference assemhly and references ahout osteoporosis in the latest 8 years hefore August 2003 were coilected, and 8 randomized controlled clinical trials accorded with the inclusive criteria were retrieved. The curative effect of 1 085 patients after the treatment nf Gusukang was enllected, and the Meta analysis of the constituent ratio of type 1 and 2 nsteoporosis was performed. The related factors of gender, age, sites and methods of hone mineral density, significant effective rate, disease course, and the actual number of cases complicated with fracture were summed up and integrated, and the percentage of eases to the total eases was calculated. The more reliahle curative effect of Gusukang on which type of osteopnrosis was evaluated according the number of case samples and percentage of ;he ease samples, The curative effect was taken as not reliable if the patient cases were less than 54 （5%）. RESULTS： ① The clinical effect in the Gusukang treated group was significantly higher than that in the other control groups, the significant effective rate was above 70%. ② Most of the patients were females with type 1 osteoporosis. Less than 5% of the cases were type 2 osteoporosis. CONCLUSION： Gusukang has significant clinical curative effect on postmenopausal females with type 1 ostenporosis, including those complicated by mild fraetnre, it also has effect on male patients. The synthetic action of Gusukang and calciant agent can enhance the effect.The effect of Gusukang nn elderly, patients with type 2 osteoporosis is still not certain, related conclusion needs further study. Whether Gusukang can improve bone mineral density is difficult to make sure, also needs further study,