期刊文献+

治疗阿尔茨海默病的胆碱酯酶抑制剂的研究进展 被引量:5

下载PDF
导出
摘要 阿尔茨海默病(AD)即早老性痴呆的患病率正逐年升高。胆碱酯酶抑制剂通过抑制酶的活性,阻止内源性乙酰胆碱的降解,增强了乙酰胆碱对脑胆碱受体的作用,提高AD患者的胆碱神经功能。对他克林、多奈哌齐、利斯的明3种胆碱酯酶抑制剂的药理作用、药代动力学、安全性及耐受性、药物相互作用进行了介绍。
出处 《中国药业》 CAS 2005年第10期78-79,共2页 China Pharmaceuticals
  • 相关文献

参考文献8

二级参考文献49

  • 1杜尊铭,李淑兰,徐嗣荪.对比复方吡拉西坦与安慰剂治疗阿耳茨海默病[J].新药与临床,1996,15(4):225-228. 被引量:5
  • 2Verrico MM, Nace DA,Towers AL. Fulminant chemical hepatitis possibly associated with donepezil and sertraline therapy[J]. J Am Geriatr Soc, 2000, 48(12) : 1659.
  • 3Calvo- Romero JM, Ramos- Salado JL.Symptomatic sinus bradycardia associated with donepezil[J]. Rev Neurol, 1999, 28(11) : 1070.
  • 4Carcenac D,Martin - Hunyadi C,Kiesmann M, et al .Extra- pyramidal syndrome induced by donepezil[J]. Presse Med, 2000, 29(18) : 992.
  • 5Staff RT, Gemmell HG, Shanks MF, et al .Changes in the rCBF images of patients with Alzheimer' s disease receiving Donepezil therapy[J] . Nucl Med Commun,2000, 21(1): 37.
  • 6Tsukada H, Sato K, Kakiuchi T, et al .Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain[J]. Brain Res, 2000, 857(1) : 158.
  • 7Reeves RR, Struve FA, Patrick G, et al .The effects of donepezil on the P300 auditory and visual cognitive evoked potentials of patients with Alzheimer' s disease[J] .Am J Geriatr Psychiatry, 1999,7(4) :349.
  • 8Svensson AL, Nordberg A.Tacrine and donepezil attenuate the neurotoxic effect of A beta(25- 35) in rat PC12 cells[J]. Neuroreport, 1998, 9(7) : 1519.
  • 9Zhang HY,Tang XC.Huperzine B,a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells[J] . Neurosci Lett, 2000, 292(1):41.
  • 10Borroni B, Colciaghi F,Pastorino L, et al .Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment [J] . Arch Neurol, 2001, 58(3) : 442.

共引文献45

同被引文献43

引证文献5

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部