2005年广州市流行性脑脊髓膜炎的临床特征分析

Analysis of Clinical Characteristics of Epidemic Cerebrospinal Meningitis in Guangzhou in 2005

目的探讨2005年广州市流行性脑脊髓膜炎流行的临床特征,提高临床医师对流行性脑脊髓膜炎的全面认识和加强预防措施。方法将2005年春收治入院的所有30例流行性脑脊髓膜炎患者进行流行特点和临床特征分析。结果流行性脑脊髓膜炎发病有群体聚集性。临床表现为发热(100%),头痛(96.67%),呕吐(86.67%),意识障碍(40%),伴颈抵抗(93.33%),淤点或淤斑(66.67%),CSF异常(100%),白细胞升高(100%),合并有中毒性心肌炎、肾损害为主。结论本次流行性脑脊髓膜炎流行是近年少见的,以民工为主。临床表现典型但无特异性,合并有多脏器损害,强调以预防为主,防治结合。

Objective To investigate the clinical characteristics of epidemic cerebrospinal meningitis in Guangzhou in 2005, and to arose the awareness of physicians of the disease and strengthen the preventive measures. Methods The clinical data of 30 hospitalized cases with epidemic eerebrospinal meningitis in our hospitals in 2005 were retrospectively analyzed to study the epidemic features and clinical characteristics of epidemic cerebrospinal meningitis. Results Epidemic cerebrospinal meningitis had the character of colony gathering. Clinical manifestations included fever （100%）, headache （96.6%）, vomit （86.67%）, unconsciousness （40%）, cervical rigidity （100%）, petechia and ecchymosis （66.67%）, abnormal examination of cerebrospinal fluid （100%）, and leukocytosis （100%）. The main complications were toxic myocarditis and renal function damage.Conclusions The outbreak of epidemic cerebrospinal meningitis in Guangzhou this year was rare in this region, and the cases mainly occurred in the group of labors. Clinical manifestations were typical without other special features. Epidemic cerebrospinal meningitis often caused multiple organ damage. To control the disease, we should mainly depend on prevention and medical treatment.