60例银屑病患者中药治疗分析及血清总IgE、嗜酸细胞阳离子蛋白的变化

Changes of Serum t-IgE and Eosinophil Cationic Protein in 60 Patients with Psoriasis and Analysing the Treatment with Traditional Chinese Medicine

目的观察银屑病患者辨证治疗疗效及血清t-IgE、嗜酸细胞阳离子蛋白(eosinophil cationic protein,ECP)的变化。方法60例患者分3型辨证治疗,疗程8周。同时采用荧光酶联免疫法测定血清t-IgE、ECP,与病期、皮损类型、瘙痒及病情严重程度进行相关性分析,对治疗后皮损消退或大部消退的部分病例进行治疗后t-IgE和ECP水平检测。结果辨证治疗总有效率为66.6%。与正常人比较,银屑病患者血清t-IgE和ECP水平显著升高,两者与病期、皮损类型及病情严重程度无显著相关,ECP水平与瘙痒程度显著相关,经中药治疗病情缓解,t-IgE水平有下降趋势,ECP部分病例下降,部分病例反而上升,但统计学无差异。结论中医辨证治疗对银屑病有较好的疗效。IgE与ECP可能参与银屑病发病过程,ECP在银屑病皮损和瘙痒中起部分作用。

Objective To study the effects of traditional Chinese medicine （TCM） on treating psoriasis and serum levels of t-IgE and eosinophil cationic protein （ECP）in patients. Methods 60 patients nere treated with TCM for a course of 8 weeks. The serum levels of t-IgE and ECP in these patients were measured with fluorescent enzyme immunoassay. The correlation of disease severity, stadium, type of skin lesion with t-IgE and ECP were identified. Then compared the serum of t-IgE and ECP in 15 patients before and after the treatment. Results The total effective rate of TCM treatment was 66.6%. Being compared with normal people, significant differences were found in serum of t-IgE and ECP in patients with psoriasis. Both t-IgE and ECP had no correlation with statistics, type of skin lesion and PASI in the patients. ECP was correlated with itching, and serum of t-IgE was lowered by the treatment of TCM. Conclusion TCM treatment has satisfied effect on treating psoriasis. T-IgE and ECP may be involved in the pathogenesis of psoriasis. ECP may take some effects on the lesions and itching from psoriasis.